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寨卡病毒让你心神不定吗?与吉兰-巴雷综合征的关联
Zika Getting on Your Nerves? The Association with the Guillain–Barré Syndrome


Jennifer A. Frontera ... 其他 • 2016.10.20

做好寨卡病毒病相关吉兰-巴雷综合征监测


王宇

中国疾病预防控制中心  

 

寨卡病毒感染,除已证实与新生儿小头畸形有关外,还可能会引发吉兰-巴雷综合征1。近期已有报告,揭示拉丁美洲7个国家寨卡病毒病爆发与吉兰-巴雷综合征病例上升存在人群、时空的密切关联2。我们都在期待着两者间更为直接的证据。

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Parra等在本刊上报告了一项前瞻性研究结果1。该研究发现68例哥伦比亚患者罹患一种综合征,符合吉兰-巴雷综合征表现,而其中的66例发病前曾有寨卡病毒(ZIKV)感染的症状。该研究的主要优势包括对吉兰-巴雷综合征与ZIKV感染的时间关系的证明(表现为ZIKV传入哥伦比亚后,全国的吉兰-巴雷综合征从20例/月增加至90例/月,发病率显著增加),采用的吉兰-巴雷综合征诊断标准,以及在血清、脑脊液和尿液分析中所获得的黄病毒的分子与血清学数据。





作者信息

Jennifer A. Frontera, M.D., and Ivan R.F. da Silva, M.D., Ph.D

 

参考文献

1. Parra B, Lizarazo J, Jiménez-Arango JA, et al. Guillain–Barré syndrome associated with Zika virus infection in Colombia. N Engl J Med 2016;375:1513-1523

2. Mansfield KL, Horton DL, Johnson N, et al. Flavivirus-induced antibody cross-reactivity. J Gen Virol 2011;92:2821-2829

3. Update on interim Zika virus clinical guidance and recommendations: Clinician Outreach and Communication Activity (COCA) call. Atlanta: Centers for Disease Control and Prevention, February 25, 2016 (http://emergency.cdc.gov/coca/ppt/2016/03_3_16_zika_update.pdf).

4. Laboratory testing for Zika virus infection. Geneva: World Health Organization, March 23, 2016 (http://apps.who.int/iris/bitstream/10665/204671/1/WHO_ZIKV_LAB_16.1_eng.pdf?ua=1).

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7. Hill AB. The environment and disease: association or causation? Proc R Soc Med 1965;58:295-300

8. Cao-Lormeau VM, Blake A, Mons S, et al. Guillain-Barré syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 2016;387:1531-1539

9. da Silva IR, Frontera JA, Moreira do Nascimento OJ. News from the battlefront: Zika virus-associated Guillain-Barré syndrome in Brazil. Neurology 2016 July 15 (Epub ahead of print)

10. Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 2016;18:587-590

11. Lucchese G, Kanduc D. Zika virus and autoimmunity: from microcephaly to Guillain-Barré syndrome, and beyond. Autoimmun Rev 2016;15:801-808

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