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羟氯喹预防COVID-19——寻求证据
Hydroxychloroquine for the Prevention of Covid-19 — Searching for Evidence


Myron S. Cohen ... 呼吸系统疾病 • 2020.08.06
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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是2019冠状病毒病(COVID-19)的病原体,其引起了全球性大流行。阻断其传播有赖于采取药物和非药物的联合干预措施。最初的SARS-CoV-2预防措施包括社交疏远、佩戴口罩、环境卫生和洗手1。预防SARS-CoV-2感染最重要的药物干预措施可能是接种疫苗,但利用现有药物进行短期预防是一种可以立即投入应用的方法。

一些研究人员在推动氯喹和羟氯喹用于治疗和预防多种微生物感染,包括SARS-CoV 2。体外试验发现羟氯喹可以抑制SARS-CoV-2复制3。一些观察性研究表明,羟氯喹治疗COVID-19有一定疗效,但其他治疗性试验则报告了不同结果4





作者信息

Myron S. Cohen, M.D.
From the Institute for Global Heath and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill.

 

参考文献

1. Cohen MS, Corey L. Combination prevention for COVID-19. Science 2020;368:551-551.

2. Rolain J-M, Colson P, Raoult D. Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int J Antimicrob Agents 2007;30:297-308.

3. Yao T-T, Qian J-D, Zhu W-Y, Wang Y, Wang G-Q. A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus — a possible reference for coronavirus disease-19 treatment option. J Med Virol 2020;92:556-563.

4. Hernandez AV, Roman YM, Pasupuleti V, Barboza JJ, White CM. Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: a living systematic review. Ann Intern Med 2020 May 27 (Epub ahead of print).

5. Boulware DR, Pullen MF, Bangdiwala AS, et al. A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. N Engl J Med 2020;383:517-525.

6. Tostmann A, Bradley J, Bousema T, et al. Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020. Euro Surveill 2020;25(16):2000508-2000508.

7. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020 February 24 (Epub ahead of print).

8. Sheahan TP, Sims AC, Zhou S, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med 2020;12:12-12(541):eabb5883-eabb5883.

9. Magagnoli J, Narendran S, Pereira F, et al. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. April 16, 2020 (https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v2. opens in new tab). preprint.

10. Sayare S. He was a science star. Then he promoted a questionable cure for COVID-19. New York Times Magazine. May 12, 2020 (https://www.nytimes.com/2020/05/12/magazine/didier-raoult-hydroxychloroquine.html. opens in new tab).

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