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儿童多系统炎症综合征——COVID-19大流行期间面临的新挑战
Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic


Michael Levin ... 呼吸系统疾病 妇产科和儿科 • 2020.07.23
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• 美国儿童和青少年中的多系统炎症综合征 • 2020年1月初在中国武汉儿童中检出的COVID-19 • 儿童感染SARS-CoV-2的情况

认识和描述新疾病的过程往往就像盲人摸象,人人都说他们摸到的就是整个大象。随着COVID-19疫情的发展,逐渐出现了描述儿童异常发热的病例报告,其中患儿的病情具有川崎病1、中毒性休克综合征2、急腹症和脑病的特征,还有关于儿童发热、炎症标志物升高及多系统受累的病例报告3-5。现在我们可以看出这些病例报告描述的是一种儿童新型炎性疾病的不同临床表现 。

一种新型疾病的病例定义于2020年4月下旬发布5,因为英国儿科医师之前向英国国民卫生服务体系(National Health Service)发出预警,称出现一种不寻常的炎性疾病,并将其命名为“与严重急性呼吸综合征冠状病毒2(SARS-CoV-2)有时间关联的儿童多系统炎症综合征”,或缩写为PIMS-TS6。其他许多国家也迅速报告了类似病例3,4。美国CDC和WHO随后各自针对该疾病发布了具有疾病鉴别意义的定义,并将其命名为儿童多系统炎症综合征(MIS-C)。





作者信息

Michael Levin, F.Med.Sci., Ph.D.
From the Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London.

 

参考文献

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2. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020;395:1607-1608.

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5. Royal College of Paediatrics and Child Health. Guidance — paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19. opens in new tab).

6. Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020 June 8 (Epub ahead of print).

7. Dufort EM, Koumans EH, Chow EJ, et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med 2020;383:347-358.

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