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将患者重新恢复为整体——从社会医学和网络医学看还原论的局限性
Putting the Patient Back Together — Social Medicine, Network Medicine, and the Limits of Reductionism


Jeremy A. Greene ... 其他 • 2017.12.21

21世纪生物医学研究和临床实践的框架,已经开始从通过仔细检查身体的患病部分(器官、组织、细胞或分子)归纳总结出疾病通用模型,转向拥趸“个体化医疗”并关注(至少是在名义上)“完整的人”,将整个人作为一个分析单位。现代早期的观点将患者看作“患病的人”,这个“患病的人”的疾病与其综合的体质遗传和生活经历密不可分1。从表面上看,上述转变似乎标志着向这种观点的回归。

但在实践中,个体化医学却往往仍然将患者还原为一系列带有详细临床表型分型的精准分子序列(“精准医学”)。生物医学研究和临床实践试图将这些原子化的碎片组装为有意义的整体,而事实证明,将患者重新恢复为一个整体的过程极为复杂。





作者信息

Jeremy A. Greene, M.D., Ph.D., and Joseph Loscalzo, M.D., Ph.D.
From the Departments of Medicine and the History of Medicine and the Center for Medical Humanities and Social Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.); and the Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston (J.L.).

 

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