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关于无糖或含糖饮料与儿童体重关系的一项临床试验
A Trial of Sugar-free or Sugar-Sweetened Beverages and Body Weight in Children


Janne C. de Ruyter ... 围产医学和儿科 • 2012.10.11
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摘要


背景

饮用含糖饮料与体重超重有相关性,可能是因为液体糖不会产生饱足感,因此不会减少其他食物的摄入。但我们缺乏数据显示用无热量饮料代替含糖饮料可以减少体重增加。

 

方法

我们进行了一项为期18个月的临床试验,试验包括641名初始时体重正常,年龄为4岁10个月到11岁11个月的儿童。参与者被随机分配为每天喝250 mL(8盎司)的无糖人造甜味饮料(无糖组),或者喝一种类似的可提供104 kcal热量的含糖饮料(含糖组)。饮料通过学校发放。在第18个月,26%的儿童已停止饮用饮料;这部分没有完成研究流程的儿童数据根据推算得到。

 

结果

体质指数(BMI,以千克为单位的体重除以米为单位的身高平方数)的z评分在无糖组中平均增加了0.02单位标准差,在含糖组中增加了0.15单位标准差;差别的95%可信区间(CI)为(-0.21)~(-0.05)。无糖组体重增加了6.35 kg,而含糖组增加了7.37 kg;差异的95%可信区间为(-1.54)~(-0.48)。无糖组的皮褶厚度、腰围与身高的比例,以及体脂含量的增加也比含糖组显著降低。不良事件很少。当我们将136名在第18个月时中断研究的儿童测量数据与477名完成研究过程的儿童数据合并时,体质指数的z评分在无糖组中增加了0.06单位标准差,在含糖组中增加了0.12单位标准差(P=0.06)。

 

结论

我们用无热量饮料来掩蔽代替含糖饮料,在正常体重儿童中减少了体重增加和脂肪积累(本研究由荷兰健康研究与发展组织[Netherlands Organization for Health Research and Development]等资助。DRINK研究在ClinicalTrials.gov注册号为NCT00893529)。





作者信息

Janne C. de Ruyter, M.Sc., Margreet R. Olthof, Ph.D., Jacob C. Seidell, Ph.D., and Martijn B. Katan, Ph.D.
From the Department of Health Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, the Netherlands. Address reprint requests to Ms. de Ruyter at VU University, Faculty of Earth and Life Sciences, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands, or at j.c.de.ruyter@vu.nl.

 

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