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含糖饮料对青少年体重影响的随机化研究
A Randomized Trial of Sugar-Sweetened Beverages and Adolescent Body Weight


Cara B. Ebbeling ... 糖尿病 围产医学和儿科 • 2012.10.11
相关阅读
• 青少年饮用运动饮料的情况 • 隔日断食效果不优于常规的低热量饮食 • 2002~2012年青少年儿童1型和2型糖尿病的发病趋势

摘要


背景

饮用含糖饮料可能导致体重过度增加。我们的目的是通过在家中给予超重和肥胖青少年包括无热量饮料在内的干预来评估这种干预对体重增加的影响。

 

方法

我们将224名经常饮用含糖饮料的超重和肥胖青少年随机分配到试验组和对照组。对试验组进行1年干预,该设计的目的是减少含糖饮料摄入;之后在不进行干预的情况下随访1年。研究假设为试验组体重与对照组相比增长较缓慢。

 

结果

参与者1年时保留率为97%,2年时为93%。基线时,试验组和对照组报告的含糖饮料消费量相似(每天1.7份);在1年时,试验组饮用含糖饮料下降至接近0,在2年时仍少于对照组。2年时,研究的主要结局指标体质指数(BMI,以体重的千克数除以身高米数的平方)变化没有显著性差异(试验组对对照组,-0.3;P=0.46)。但在1年时,两组间的BMI变化值(−0.57,P=0.045)和体重变化值(−1.9 kg,P=0.04)的差异显著。根据民族进行亚组分析,我们发现了1年(P=0.04)和2年(P=0.01)时效果改变的证据。在预设的按照民族进行的分析中,西班牙语裔参与者(试验组27例、对照组19例)的BMI的变化在1年(−1.79,P=0.007)和2年(−2.35,P=0.01)时均有显著的组间差异,但非西班牙语裔参与者则无显著性的组间差异(1年和2年时P均>0.35)。2年时两组参与者的体脂占体重百分比变化没有显著性差异(−0.5%,P=0.40)。全部参与者均未发生与参与研究相关的不良事件。

 

结论 

减少含糖饮料摄入1年,试验组超重和肥胖青少年的BMI较对照组增加幅度小,但在随访2年时无显著差异(预设的主要结局指标)(由国家糖尿病消化疾病和肾脏病研究所[National Institute of Diabetes and Digestive and Kidney Diseases]等资助;ClinicalTrials.gov注册号为NCT00381160)。





作者信息

Cara B. Ebbeling, Ph.D., Henry A. Feldman, Ph.D., Virginia R. Chomitz, Ph.D., Tracy A. Antonelli, M.P.H., Steven L. Gortmaker, Ph.D., Stavroula K. Osganian, M.D., Sc.D., and David S. Ludwig, M.D., Ph.D.
From the New Balance Foundation Obesity Prevention Center (C.B.E., D.S.L.) and the Clinical Research Center (H.A.F., T.A.A., S.K.O.), Boston Children's Hospital, Boston; the Institute for Community Health, Cambridge (V.R.C.); and the Department of Society, Human Development, and Health, Harvard School of Public Health, Boston (S.L.G.) — all in Massachusetts. Address reprint requests to Dr. Ludwig at the New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, or at david.ludwig@childrens.harvard.edu.

 

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