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Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes

Lise G. Bjerregaard ... 糖尿病 • 2018.04.05
• 儿童和青少年的心脏代谢风险与肥胖严重程度 • 儿童期体重减轻与2型糖尿病风险降低相关 • 新发2型糖尿病成年患者的体质指数与死亡率









在7岁(62,565人中的3,373人;5.4%)、13岁(62,565人中的3,418人;5.5%)或成年早期(62,565人中的5,108人;8.2%)时超重与2型糖尿病风险呈正相关;当超重时年龄大、诊断2型糖尿病时年龄小时,相关性更强。在13岁之前消除超重的男性中,在30~60岁被诊断为2型糖尿病的风险与从未超重的男性相似(风险比,0.96;95%置信区间[CI],0.75~1.21)。与从未超重的男性相比,在7岁和13岁时超重但在成年早期不超重的男性患2型糖尿病的风险较高(风险比,1.47;95% CI,1.10~1.98),但他们的风险低于持续超重的男性(风险比,4.14;95% CI,3.57~4.79)。从7岁至成年早期的体质指数增加与2型糖尿病风险增加相关,即使7岁时体重正常的男性亦如此。





Lise G. Bjerregaard, Ph.D., Britt W. Jensen, Ph.D., Lars Ängquist, Ph.D., Merete Osler, D.M.Sc., Thorkild I.A. Sørensen, D.M.Sc., and Jennifer L. Baker, Ph.D.
From the Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital (L.G.B., B.W.J., L.Ä, M.O., J.L.B.), and the Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences (T.I.A.S., J.L.B.), and the Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences (T.I.A.S.), University of Copenhagen — all in Copenhagen. Address reprint requests to Dr. Bjerregaard at the Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark, or at lise.geisler.bjerregaard@regionh.dk.



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