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宫颈癌的经阴道母婴传播
Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants


Ayumu Arakawa ... 肿瘤 妇产科和儿科 • 2021.01.07

摘要


对肿瘤和正常组织配对样本进行常规二代测序的过程中,我们偶然发现了2例因宫颈肿瘤母婴传播引起的儿童肺癌(分别为23月龄和6岁男童)。第一例患儿的一些病灶自发消退,第二例患儿的肿块生长缓慢,这提示存在针对上述母婴传播肿瘤的同种免疫应答。使用纳武利尤单抗进行的免疫检查点抑制治疗使第一例患儿的其余所有肿瘤显著消退(由日本医疗研究开发机构[Japan Agency for Medical Research and Development]等资助,TOP-GEAR在UMIN Clinical Trials注册号为UMIN000011141)。





作者信息

Ayumu Arakawa, M.D., Hitoshi Ichikawa, Ph.D., Takashi Kubo, Ph.D., Noriko Motoi, M.D., Ph.D., Tadashi Kumamoto, M.D., Ph.D., Miho Nakajima, M.D., Kan Yonemori, M.D., Ph.D., Emi Noguchi, M.D., Ph.D., Kuniko Sunami, M.D., Ph.D., Kouya Shiraishi, Ph.D., Hiroki Kakishima, Hiroshi Yoshida, M.D., Ph.D., Tomoro Hishiki, M.D., Ph.D., Naonori Kawakubo, M.D., Ph.D., Takafumi Kuroda, M.D., Takako Kiyokawa, M.D., Ph.D., Kyosuke Yamada, M.D., Ph.D., Nozomu Yanaihara, M.D., Ph.D., Kazuaki Takahashi, M.D., Ph.D., Aikou Okamoto, M.D., Ph.D., Shinsuke Hirabayashi, M.D., Ph.D., Daisuke Hasegawa, M.D., Ph.D., Atsushi Manabe, M.D., Ph.D., Kentaro Ono, M.D., Masaki Matsuoka, M.D., Yasuhito Arai, Ph.D., Yosuke Togashi, M.D., Ph.D., Tatsuhiro Shibata, M.D., Ph.D., Hiroyoshi Nishikawa, M.D., Ph.D., Kazunori Aoki, M.D., Ph.D., Noboru Yamamoto, M.D., Ph.D., Takashi Kohno, Ph.D., and Chitose Ogawa, M.D.
From the Departments of Pediatric Oncology (A.A., T. Kumamoto, M.N., C.O.), Laboratory Medicine (T. Kubo, K. Sunami, H.K.), Diagnostic Pathology (N.M., H.Y.), Breast and Medical Oncology (K. Yonemori, E.N.), Pediatric Surgical Oncology (T.H., N.K.), and Experimental Therapeutics (N. Yamamoto), National Cancer Center Hospital, the Departments of Clinical Genomics (H.I., T. Kubo) and Immune Medicine (K.A.), and the Divisions of Genome Biology (K. Shiraishi, T. Kohno), Cancer Genomics (Y.A., T.S.), and Cancer Immunology (Y.T., H.N.), National Cancer Center Research Institute, the Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center (H.I., T. Kubo, T. Kohno), the Children’s Cancer Center, National Center for Child Health and Development (T.H.), the Departments of Obstetrics and Gynecology (T. Kuroda, K. Yamada, N. Yanaihara, K. Takahashi, A.O.) and Pathology (T. Kiyokawa), Jikei University School of Medicine, the Departments of Pediatrics (S.H., D.H., A.M.) and Integrated Women’s Health (K.O.), St. Luke’s International Hospital, and the Department of Pediatrics, Toho University School of Medicine (M.M.), Tokyo, and the Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo (S.H., A.M.) — both in Japan. Address reprint requests to Dr. Kohno or Dr. Ogawa at the National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo 1040045, Japan, or at tkkohno@ncc.go.jp or chitogaw@ncc.go.jp.

 

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