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拯救濒危的医师科学家——一项加速推进医学突破的计划
Saving the Endangered Physician-Scientist — A Plan for Accelerating Medical Breakthroughs


Mukesh K. Jain ... 其他 • 2019.08.01

1968年7月1日,在越南战争最激烈的时候,四名几乎没有或完全没有科研背景的年轻医生来到美国国立卫生研究院(NIH)报到,开始作为美国公共卫生署(U.S. Public Health Service,USPHS)军官履行兵役。这段为期2年的经历促使四人将科研纳入其医生职业规划。他们之后取得的成就包括:发现癌基因;开展最终促使他汀类药物研发成功的研究;发现一个受体家族,而美国食品药品管理局目前批准的所有药物中,有1/3以该受体家族作为靶点;锦上添花的是他们还获得了四项诺贝尔奖。这四位医师科学家是哈罗德·瓦穆斯(Harold Varmus)、迈克尔·布朗(Michael Brown)、约瑟夫·戈尔茨坦(Joseph Goldstein)以及我们几位作者之一的罗伯特·莱夫科维茨(Robert Lefkowitz),他们的努力将永远改变科学和医学。





作者信息

Mukesh K. Jain, M.D., Vivian G. Cheung, M.D., Paul J. Utz, M.D., Brian K. Kobilka, M.D., Tadataka Yamada, M.D., and Robert Lefkowitz, M.D.
From the Harrington Discovery Institute and the Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, and the Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland (M.K.J.); the Howard Hughes Medical Institute and the Departments of Pediatrics and Genetics, University of Michigan, Ann Arbor (V.G.C.); the Department of Medicine and the Institute for Immunity, Transplantation, and Infection (P.J.U.), and the Department of Molecular and Cellular Physiology (B.K.K.), Stanford University School of Medicine, Stanford, CA; Frazier Healthcare Partners, Seattle (T.Y.); and the Howard Hughes Medical Institute and the Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC (R.L.).

 

参考文献

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2. Physician-Scientist Workforce Working Group report. Bethesda, MD: National Institutes of Health, June 1, 2014 (http://acd.od.nih.gov/reports/PSW_Report_ACD_06042014.pdfopens in new tab).

3. Wong MD, Guerrero L, Sallam T, Frank JS, Fogelman AM, Demer LL. Outcomes of a novel training program for physician-scientists: integrating graduate degree training with specialty fellowship. J Grad Med Educ 2016;8:85-90.

4. Goldstein JL, Brown MS. History of science: a golden era of Nobel laureates. Science 2012;338:1033-1034.

5. Ognibene FP, Gallin JI, Baum BJ, Wyatt RG, Gottesman MM. Outcomes from the NIH Clinical Research Training Program: a mentored research experience to enhance career development of clinician-scientists. Acad Med 2016;91:1684-1690.

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