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Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Harald Zeisler ... 妇产科和儿科 • 2016.01.07
• 通过测定孕妇的胎盘生长因子来加速先兆子痫的诊断 • 补钙可否降低复发性先兆子痫的发生风险









在开发队列中(500名女性),我们确定sFlt-1∶PlGF比值临界值38具有重要的预测价值。在另外550名女性中进行的后续验证研究中,sFlt-1∶PlGF比值为38或更低的阴性预测值(即在随后1周内不会出现先兆子痫)为99.3%(95%置信区间[CI],97.9~99.9),敏感性为80%(95% CI,51.9~95.7),特异性为78.3%(95% CI,74.6~ 81.7)。对于4周内诊断先兆子痫,sFlt-1∶PlGF比值高于38的阳性预测值为36.7%(95% CI,28.4~45.7),敏感性为66.2%(95% CI,54.0~77.0),特异性为83.1%(95% CI,79.4~86.3)。



在临床上疑似先兆子痫的女性中,sFlt-1∶PlGF比值为38或更低可用于预测短期内不会发生先兆子痫(由罗氏诊断公司[Roche Diagnostics]资助)。


Harald Zeisler, M.D., Elisa Llurba, M.D., Ph.D., Frederic Chantraine, M.D., Ph.D., Manu Vatish, M.B., Ch.B., D.Phil., Anne Cathrine Staff, M.D., Ph.D., Maria Sennström, M.D., Ph.D., Matts Olovsson, M.D., Ph.D., Shaun P. Brennecke, M.B., B.S., D.Phil., Holger Stepan, M.D., Deirdre Allegranza, B.A., Peter Dilba, M.Sc., Maria Schoedl, Ph.D., Martin Hund, Ph.D., and Stefan Verlohren, M.D., Ph.D.
From the Department of Obstetrics and Gynecology, Medical University Vienna, Vienna (H.Z.); the Department of Obstetrics, Maternal–Fetal Medicine Unit, Hospital Universitari Vall d’Hebron, Barcelona, and the Maternal and Child Health and Development Network, Instituto de Salud Carlos III, Madrid (E.L.); the Department of Obstetrics and Gynecology, University of Liege, Liege, Belgium (F.C.); Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom (M.V.); the Departments of Gynecology and Obstetrics, Oslo University Hospital, and University of Oslo, Oslo (A.C.S.); the Department of Women’s and Children’s Health, Karolinska University Hospital, and Karolinska Institute, Stockholm (M. Sennström), and the Department of Women’s and Children’s Health, Uppsala University, Uppsala (M.O.) — both in Sweden; Pregnancy Research Centre, Department of Perinatal Medicine, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, Australia (S.P.B.); the Department of Obstetrics, University of Leipzig, Leipzig (H.S.), Roche Diagnostics, Penzberg (P.D., M. Schoedl), and the Department of Obstetrics, Campus Virchow–Klinikum Charité, Berlin (S.V.) — all in Germany; and Roche Diagnostics International, Rotkreuz, Switzerland (D.A., M.H.). Address reprint requests to Dr. Verlohren at the Department of Obstetrics, Campus Virchow–Klinikum Charité, Augustenburger Pl. 1, D-13353 Berlin, Germany, or at stefan.verlohren@charite.de.



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